HNS Antibody

HNS Antikorpo

Sinonimoj Kontraŭhoma IgG Fc Monoklona Malĉefa Antikorpo (Min X Ms, Rt, Rb, Ch, Gt)
Priskribo Ĝenerale, kapraj kontraŭhomaj aŭ azenaj kontraŭhomaj IgG-poliklonaj antikorpoj estas uzataj kiel la duaranga antikorpo por detekti homajn primarajn antikorpojn. Tamen, ĉar plurklonaj antikorpoj povas rekoni multajn epitopojn, la fono kaj la kruca reagemo en la provoj estas kutime altaj, kio malfaciligas la rezultojn interpreti.
Por minimumigi la fonon kaj transversan reagemon kaj plibonigi mult -al-multan konsistencon, unikan  GenScript Mouse Anti-Human IgG Fc Antibody (50B4A9) [HRP], mAb  estis disvolvita por esti uzata kiel duaranga antikorpo. La supereco de ĉi tiu antikorpo estas, ke ĝi povas esti uzata kiel idiotipa antikorpo por detekti drogan metabolon in vivo.
Gastigantaj Specioj Muso
Antigena Specio Homa
Konjugacio Peroksidazo (Kreno)
Immunogen Homa IgG (H&L)
Purigo Proteina A-afineca kolono

 

 

Laboraj koncentriĝoj por specifaj aplikoj devas esti determinitaj de la enketisto. La taŭgaj koncentriĝoj povas esti trafitaj de primara antikorpa afineco, antigena koncentriĝo, la sentemo de la metodo de detekto, temperaturo, la longo de la inkubacioj kaj aliaj faktoroj. La taŭgeco de ĉi tiu antikorpo por aplikoj krom tiuj listigitaj sube ne estis determinita. La jenaj koncentriĝaj gamoj rekomendas komencajn punktojn por ĉi tiu produkto.

 

Kontraŭ-NHS antikorpoj estas ofertitaj de kelkaj provizantoj. Ĉi tiu cela geno kodas la proteinon “NHS-aktina remodela reguligilo” ĉe homoj kaj ankaŭ povas esti konata kiel CTRCT40, CXN, SCML1, sindromo de Nance-Horan kaj sindromo de Nance-Horan (denaskaj akvofaloj kaj dentaj anomalioj). Strukture, la proteino laŭdire havas 179,1 kilodaltonojn en maso. Surbaze de gennomo, hundaj, porkaj, simiaj, musaj kaj rataj ortologoj ankaŭ troveblas. Por pli ampleksaj informoj pri antikorpaj produktoj (kiel imunogen, specifeco, aplikoj kaj pli), vizitu la paĝon de la provizanto.

 

hns, Polyclonal Antibody
hns, Polyclonal Antibody

Abstrakta

Histon-simila nukleida struktura proteino (H-NS) estas modula proteino, kiu estas asociita kun la bakteria nukleido. Ni uzis kromatin-imunoprecipiton por determini la ligajn lokojn de H-NS kaj RNA-polimerazo sur la  Salmonella enterica  serovar-Typhimurium-kromosomo. Ni trovis, ke H-NS ne ligas al aktive transskribitaj genoj kaj ne kunlokiĝas kun RNA-polimerazo. Ĉi tio montras, ke H-NS ĉefe silentigas genan esprimon limigante la aliron de RNA-polimerazo al la DNA. H-NS antaŭe estis montrita preferate ligi al kurba DNA in vitro. Fakte, je la genomika nivelo ni malkovris, ke la nivelo de ligado de H-NS pli bone rilatas al la AT-enhavo de DNA. Ĉi tio probable havas evoluajn konsekvencojn, ĉar ni montras, ke H-NS ligas al multaj  Salmoneloj genoj akiritaj per flanka transdono de genoj, kaj funkcias kiel gena dampilo. La forigo de H-NS el la ĉelo kaŭzas nekontrolitan esprimon de pluraj  insuloj de  Salmonella patogeneco, kaj ni montras, ke ĉi tio havas malutilajn konsekvencojn por bakteria taŭgeco. Nia malkovro de ĉi tiu nova rolo por H-NS povas havi implicojn por la akiro de fremdaj genoj de enaj bakterioj .

Sinoptiko

En la lastaj jardekoj, gena silentigo estis bone karakterizita en plantoj kaj bestoj, kaj implikas la preventon de transskribo per DNA-metiligo kaj histono-modifo, aŭ enmiksiĝo kun traduko de malgrandaj RNA-molekuloj. Ĉi tiu numero de PLoS-Patogenoj raportas la malkovron, ke tutmonda gena silentigo okazas ankaŭ en bakterioj. La nova me mechanismanismo estas perata de la tre abunda histona-simila nukleida struktura proteino (H-NS), kiu blokas la esprimon de 254 genoj en sovaĝa tipo  Salmonella.. Multaj el ĉi tiuj genoj estis akiritaj per horizontala transdono de genoj, inkluzive de insuloj de patogeneco, kaj ĉi tiuj estas silentigitaj per la ligo de H-NS al AT-riĉaj kromosomaj regionoj. La studo malkaŝas, ke H-NS malhelpas la nekontrolitan transskribon de genoj ene de patogenaj insuloj por certigi, ke bakteria taŭgeco estas konservata. Estas sugestite ke H-NS ludas rolon en bakteria evoluo influante kaj la akiron kaj prizorgadon de fremda DNA.

 

 

anti- Antibody^Polyclonal antibody control antibody

LSMab09882 100 ug
EUR 438

Antibody

A1360-500 Ask for price

Anti-Anti-SEPT2 Antibody antibody

STJ25475 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-SEPT8 Antibody antibody

STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT2 Antibody antibody

STJ28365 100 µl
EUR 277

Anti-Anti-SEPT7 Antibody antibody

STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-SEPT8 Antibody antibody

STJ117206 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT12 Antibody antibody

STJ117759 100 µl
EUR 277
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-MARCH6 Antibody antibody

STJ118549 100 µl
EUR 277

Anti-Anti-MARCH6 Antibody antibody

STJ118550 100 µl
EUR 277

Anti-Anti-MARCH7 Antibody antibody

STJ118752 100 µl
EUR 277

Anti-Anti-SEPT3 Antibody antibody

STJ118990 100 µl
EUR 277

Anti-Anti-SEPT1 antibody antibody

STJ119580 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

Anti-Anti-SEPT7 Antibody antibody

STJ116214 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-SEPT6 antibody antibody

STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.

Anti-Anti-SEPT9 Antibody antibody

STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.

Anti-Anti-SEPT11 Antibody antibody

STJ111530 100 µl
EUR 277

Anti-Anti-SEPT4 Antibody antibody

STJ112276 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.

Anti-Anti-MARCH9 Antibody antibody

STJ112609 100 µl
EUR 277

Anti-Anti-SEPT11 Antibody antibody

STJ113941 100 µl
EUR 277

Anti-Anti-SEPT11 Antibody antibody

STJ114081 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ114819 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-MARCH8 Antibody antibody

STJ114828 100 µl
EUR 277

Ly1 Antibody Reactive (LYAR) Antibody

20-abx123734
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul

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